Imagery Rescripting (ImRs) is an experiential method to process memories of traumatic events and other negative experiences that lie at the root of patients’ problems. In Imagery Rescripting patients imagine the original experience but alter the sequence of events so that their needs are better met. With very complex cases and early trauma’s, the focus is on memories from childhood and it is usually the therapist leading the Rescripting and the therapist who intervenes in fantasy to stop abuse, brings safety, and corrects misconceptions about the experience, whilst the patient imagines being the child. With less complex cases and in adult trauma/negative experiences, it is usually the patient who leads the rescripting. ImRs has a wide range of applications, from PTSD, chronic depression and treatment-resistant anxiety and eating disorders to personality disorders. Moreover, it is the standard treatment of nightmares in the US. With patients suffering from visual intrusions the application is quite straightforward as the intrusions, or the memories that they are based on, can be directly addressed in Imagery Rescripting. However with other problems, like a negative self-view or distrust in others, first memories of experiences that underlie such basic schemas need to be found. Usually the use of an ‘affect bridge’ between a recently experience of activation of the schema and a spontaneously early memory helps, and applications of this in a wide range of clinical problems have been found to be effective. Imagery Rescripting has a number of attractive elements, including its broad and flexible range of application, its focus on changing the meaning of the experience, and the fact that it is not necessary to relive the whole trauma in all its details (which increases acceptability and usefulness for very severe cases). In this keynote the clinical effectiveness of ImRs will be discussed, as well as laboratory studies into basic mechanisms that underlie ImRs, indicating that ImRs indeed works thru meaning change.