Major Depression is a complex and heterogeneous disorder that requires a formal case conceptualization model in each case. This conceptualization is needed to plan the overall clinical approach to each case, to measure treatment outcomes, and to optimize clinical strategies within each session. This workshop will provide a cognitive-behavioral framework, which will allow attendees to undertake this process of conceptualization and treatment planning. The workshop will focus on practical clinical strategies, and will include discussion of how to engage patients in the difficult process of overcoming depression. Discussion of the clinical model will be supplemented with video presentations, and clinical vignettes.